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Medicines and Stevens Johnson Syndrome ARTICLE | November 1973
Ocular Aftermath of Stevens-Johnson Syndrome

Review of 33 Cases
Maria J. Arstikaitis, MD

Arch Ophthalmol. 1973;90(5):376-379.

Of 33 cases of Stevens-Johnson syndrome treated over a 20-year period, five developed keratitis sicca with corneal pannus and one developed corneal pannus alone. The severity of the ophthalmic complications was related to the severity of the disease in its acute phase and was not related to the local treatment used on the eyes. Erythema Multiforme, Pediatric Updated 5/2012
James Treat, Albert C. Yan (5th edition)


An acute self-limited cutaneous eruption with many different or multiform lesions Characterized classically as a target or iris lesion but may appear as erythematous macules, papules, vesicles, and bullae and can be associated with mucosal involvement

There are many triggers of erythema multiforme (EM), which is thought to encompass a spectrum of disease from relatively mild disease (EM minor) to severe forms with more severe mucosal surface involved (EM major).

Although they can both present with targetoid skin lesions, many authors now feel Stevens Johnson Syndrome (SJS) and toxic epidermolysis (TEN) are separate entities from typical erythema multiforme. SJS and TEN involve ≥2 mucous membranes, and extensive skin blistering or sloughing (<10% is SJS, 10–30% is SJS-TEN overlap and >30% is TEN). SJS and TEN ...

Stevens Johnson Syndrome Medicines

Stevens-Johnson syndrome is a rare, potentially lethal disease that attacks the skin. Another form of the disease is called Toxic Epidermal Necrolysis. Both typically occur when the skin and mucous membranes react to a medication, or to a pre-existing bacterial infection or illness.

These two conditions can affect any age group. However, older adults, people with HIV, Herpes (herpes simplex or herpes zoster) are more at risk for Stevens-Johnson Syndrome or Toxic Epidermal Necrolysis.

Both Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis often start with symptoms such as cough, aching, headaches, a burning sensation in the eyes or fever. These flu-like signs are followed by a red or purple rash that spreads across the face and body, often forming blisters around the eyes, mouth or vaginal area. Facial or tongue swelling can also occur, and layers of the skin may shed away or give the appearance of being burned.